Ferritin nanocomposites for the selective delivery of photosensitizing ruthenium-polypyridyl compounds to cancer cells
نویسندگان
چکیده
Human ferritin platforms containing Ru( ii )-polypyridyl-based photosensitizers effectively target cancer cells and provide cytotoxic effects upon light-activation.
منابع مشابه
Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells.
In this work the selective uptake of native horse spleen ferritin and apoferritin loaded with MRI contrast agents has been assessed in human breast cancer cells (MCF-7 and MDA-MB-231). The higher expression of L-ferritin receptors (SCARA5) led to an enhanced uptake in MCF-7 as shown in T2 and T1 weighted MR images, respectively. The high efficiency of ferritin internalization in MCF-7 has been ...
متن کاملRuthenium(II) polypyridyl complexes as carriers for DNA delivery.
Two novel water soluble ruthenium(II) complexes [Ru(bpy)(2)(bqbg)](2+) and [Ru(phen)(2)(bqbg)](2+) have been structurally characterized and their DNA condensation activity, cytotoxicity, and cellular uptake studies of DNA condensates as potential non-viral DNA carriers were evaluated.
متن کاملHighly selective photo-catalytic dimerization of alpha-methylstyrene by a novel palladium complex with photosensitizing ruthenium(II) polypyridyl moiety.
A novel dinuclear complex containing the photo-sensitizing Ru unit and a Pd center is effective toward selective catalytic dimerization of alpha-methylstyrene leading to 2,4-diphenyl-4-methyl-1-pentene under visible-light irradiated conditions.
متن کاملRuthenium polypyridyl phototriggers: from beginnings to perspectives.
Octahedral Ru(II) polypyridyl complexes constitute a superb platform to devise photoactive triggers capable of delivering entire molecules in a reliable, fast, efficient and clean way. Ruthenium coordination chemistry opens the way to caging a wide range of molecules, such as amino acids, nucleotides, neurotransmitters, fluorescent probes and genetic inducers. Contrary to other phototriggers, t...
متن کاملRegression of lung cancer by hypoxia-sensitizing ruthenium polypyridyl complexes.
The ruthenium (II) polypyridyl complexes (RPC), Δ-[(phen)2Ru(tatpp)]Cl2 (Δ-[3]Cl2) and ΔΔ-[(phen)2Ru(tatpp)Ru(phen)2]Cl4 (ΔΔ-[4]Cl4, are a new generation of metal-based antitumor agents. These RPCs bind DNA via intercalation of the tatpp ligand, which itself is redox-active and is easily reduced at biologically relevant potentials. We have previously shown that RPC 4(4+) cleaves DNA when reduce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Inorganic chemistry frontiers
سال: 2022
ISSN: ['2052-1553', '2052-1545']
DOI: https://doi.org/10.1039/d1qi01268a